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| CAS号 [442-16-0] 生产工艺。 利凡诺 |
CAS号 [442-16-0] 生产工艺。 利凡诺
CAS名：3,9-Acridinediamine, 7-ethoxy-
历史参考文献：待检索。
用途：杀菌消毒剂。CAS号[442-16-0]. LookChem网登录生产与经营单位13家。 反应类别：硝基还原。
CAS号[1837-57-6] C15H15N3O. C3H6O3 =343.42。LookChem网登录生产与经营单位95家。
BIOS trip. 1155, 14-16. Rivanol
hydrochloride. 英国人译自德文。无资料来源。（暂未找到德文原件）。
反应式：本人有加注。CAS号[20304-70-6]。已在2018年11月2日上网，
Starting materials: Nitroaminoacridine, moist. 25 kg. iron Turnings. 2.4 kg. hydrochloric acid crude.
The moist nitro compound from [20304-70-6] is suspended in 160 l. of
water, and the suspension added in small portions to a mixture of 24 kg. iron
turnings, 2.4 kg. of hydrochloric acid and 40 l. of water at 85-95℃. The reduction takes about 2
hours and the test for completeness is when a drop of the mixture on filter
paper gives a clear yellow zone away from the centre. The iron sludge is filtered off on a heated
suction filter, be boiled up several times with 10 l. portions of water and
filtered off each time. The combined
filtrates are acidified to Congo with hydrochloric acid and treated with 2 l.
of 25% sodium chloride solution. The
crude hydrochloride is filtered off after cooling. It is warmed to 90℃. with 100 l. of water, 600 g. of aqueous ammonia are added, the
solution further heated to 100℃. with 800 g. of decolorizing charcoal and
filtered. To the filtrate 10 kg. of
hydrochloric acid and 2 l. of 25% sodium chloride solution are added as
before. This purification is repeated three
to four times until a test sample gives a clear solution at a dilution of 1 in
100 with water.
About five reduction units are in use and the filters are of porous
stoneware.
Rivanol Base: 未抄录。因为本人未收藏有这一资料，所以无法抄录上网！
（日）《有机化合物辞典》。有机合成化学协会 编。 1985年。P. 138.
エタクリジン
Ethacridine; 2-Ethoxy-6,9-acridinediamine.
CA [422-16-0]. 化审9-240.
C15H16N3O = 253.29. 结构式：略。
Mp 123-124℃. 黄色针状晶，水に不溶。【制法】2-クロロ-4-ニトロ安息香酸とp-フェネチジンより合成する。[G. Albert. J. Soc. Chem. Ind., 61, 159
(1942)].
乳酸盐水和物（アクリノ- ル。Acrinol）; CA [1837-57-6]. Mp. 245℃（分解）。10 局p.25. 黄色结晶粉末で具臭，热湯に易溶，水。沸腾エタノ- ルに易溶。【用途】杀菌消毒药。【毒性】LD 50（マウス，腹腔内）42 mg/kg.
日本医药品集，7版，p.3.
国内出版物：本人手头资料有限。
历史文献抄录有感：
从日文手册可以看出，日本人也没有提到BIOS。当然，这已是过时的历史资料！唯一可以参考的是：他们在1985年已利用了CAS号。而我们，如：张澍声 《精细化工中间体工业生产技术》一书，这是1996年的出版物，就是没有CAS号！
陈忠源 2019年7月25日星期四。继续战高温！
文章作者：陈忠源 |
